Selected Publications Sers

Relógio A, Thomas P, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C.
Ras-mediated deregulation of the circadian clock in cancer..
PLoS Genet. 2014; 10(5)
Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG, Morkel M.
Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity..
Oncogene. 2014; [Epub ahead of print]
Klinger B, Sieber A, Fritsche-Guenther R, Witzel F, Berry L, Schumacher D, Yan Y, Durek P, Merchant M, Schäfer R, Sers C, Blüthgen N.
Network quantification of EGFR signaling unveils potential for targeted combination therapy.
Mol Syst Biol. 2013; 9:673.
Stelniec-Klotz I, Legewie S, Tchernitsa O, Witzel F, Klinger B, Sers C, Herzel H, Blüthgen N, Schäfer R.
Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS.
Mol Syst Biol. 2012; 8:601.
Kuehnen P, Mischke M, Wiegand S, Sers C, Horsthemke B, Lau S, Keil T, Lee YA, Grueters A, Krude H.
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.
PLoS Genet. 2012; 8(3):e1002543.
Fritsche-Guenther R, Witzel F, Sieber A, Herr R, Schmidt N, Braun S, Brummer T, Sers C, Blüthgen N.
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.
Mol Syst Biol. 2011; 7:489.
Bormann F, Sers C, Seliger B, Handke D, Bergmann T, Seibt S, Lehrach H, Dahl A.
Methylation-specific ligation detection reaction (msLDR): a new approach for multiplex evaluation of methylation patterns.
Mol Genet Genomics. 2011; 286(3-4):279-91.
Wolkenhauer O, Auffray C, Baltrusch B, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JEJr., Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, and Jaster R.
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.
Cancer Res. 2010; 70(1):12-3.
Sers C, Kuner R, Falk CS, Lund P, Sueltmann H, Braun M, Buness A, Ruschhaupt M, Conrad J, Mang-Fatehi S, Stelniec I, Krapfenbauer U, Poustka A, Schäfer R.
Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells.
Int J Cancer 2009; 125(7):1626-39.
Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C.
A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.
FEBS J 2009; 276(4):1024-35.

Selected Publications Morkel

Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG, Morkel M.
Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity..
Oncogene. 2014; [Epub ahead of print]
Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Dietrich J, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M.
DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer.
PLoS Genet. 2013; 9(2):e1003250.
Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M.
Wnt and BMP signals control intestinal adenoma cell fates.
Int J Cancer. 2012; 131(10):2242-52.
Leushacke M, Spörle R, Bernemann C, Brouwer-Lehmitz A, Fritzmann J, Theis M, Buchholz F, Herrmann BG, Morkel M.
An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.
PLoS One. 2011; 6(8):e23381.
Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM, Birchmeier W.
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential .
Gastroenterology. 2009; 137(1):165-75.

Selected Publications Mamlouk

Mamlouk S, Wielockx B
Hypoxia-inducible factors as key regulators of tumor inflammation.
Int J Cancer 2013; 132(12):2721-9.
Mamlouk S, Kalucka J, Singh RP, Franke K, Muschter A, Langer A, Jakob C, Gassmann M, Baretton GB, Wielockx B
Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.
Int J Cancer 2014; 134(4):849-58.
Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
Blood. 2013; 121(8):1436-45.

Group leader

Prof. Dr. rer. nat. Christine Sers
Head of group Mol. Tumor Pathology, Head of group Tumor Systems Biology
t: +49 30 450 536 185